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Jorge Hernández Rodríguez is a Professor of Physiology and Biophysics and Neurosciences Department of Biophysics and Neurosciences, IPN Advanced Research and Research Centre, Av. Instituto Politécnico Nacional, Mexico.
We evaluated whether the plasma free fraction of L-Tryptophan(FFT) and the N1/P2 component of the pimary auditory cortex response-wave to specific stimuli (PACR), are associated with impaired brain serotonin(5-HT) neurotransmission in infants with IUGR (Intrauterine Growth Restriction). The FFT, total and bound plasma L-Tryptophan (L-Trp) and the N1/P2 component of PACR, were measusred in a prospective longitudinal and comparative study between IUGR and normal control infants. FFT was increased and the aplitude of N1/P2 component was remarkably diminished in IUGR, relative to control infants. These two parameters had a negative association.So,we conluded that in IUGR infants, since birth up to 60 days of posnatal life, the present results suggest an inverse association between FFT and the N1/P2 component of the auditory cortex response to specific stimuli. The changes observed in the FFT and PACR, may be causally related with an increased brain serotonergic activity in utero and in posnatal life. In IUGR, epignetic factors such as nuitritional and metabolic stress-induced disturbances in brain 5-HT metabolism and in serotonergic neuronal activity, identifiable by the alterations in PACR, may influence sensory cortex development and early morphogenetic normal changes, as we have observed in the somatosensory cortex and that in posnatal life be related to serotonin disorders in adulthood.